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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50022912
Substrate
n/a
Meas. Tech.
ChEBML_71742
Kd
0.800000±n/a nM
Citation
 Rivier, J; Kupryszewski, G; Varga, J; Porter, J; Rivier, C; Perrin, M; Hagler, A; Struthers, S; Corrigan, A; Vale, W Design of potent cyclic gonadotropin releasing hormone antagonists. J Med Chem 31:677-82 (1988) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50022912
Synonyms:
Ac-DNal-DCpa-DPal-c[Cys-Arg-DPal-Leu-Arg-Pro-Cys]-NH2 | CHEMBL439892
Type:
Small organic molecule
Emp. Form.:
C67H86ClN19O11S2
Mol. Mass.:
1433.103
SMILES:
CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)c1cccnc1)c1cccnc1
Structure:
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