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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50022914
Substrate
n/a
Meas. Tech.
ChEBML_71742
Kd
1.9±n/a nM
Citation
 Rivier, J; Kupryszewski, G; Varga, J; Porter, J; Rivier, C; Perrin, M; Hagler, A; Struthers, S; Corrigan, A; Vale, W Design of potent cyclic gonadotropin releasing hormone antagonists. J Med Chem 31:677-82 (1988) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50022914
Synonyms:
Ac-DNal-DFpa-DTrp-[Dpr-Tyr-DArg-Leu-Arg-Pro-Asp]-NH2 | CHEMBL2371274
Type:
Small organic molecule
Emp. Form.:
C72H92FN19O12
Mol. Mass.:
1434.6194
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(=O)NC[C@H](NC2=O)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](N)Cc1ccc2ccccc2c1 |wU:80.94,56.62,19.20,92.98,8.9,27.28,wD:50.65,66.81,38.39,1.0,(-10.63,7.13,;-11.56,5.52,;-12.59,6.66,;-14,6.04,;-13.84,4.51,;-12.33,4.18,;-11.3,3.04,;-9.87,3.62,;-11.23,1.36,;-12.54,.56,;-12.51,-.98,;-13.83,-1.78,;-13.79,-3.32,;-15.11,-4.12,;-15.08,-5.66,;-16.46,-3.38,;-9.89,.59,;-8.56,1.36,;-8.56,2.9,;-7.23,.59,;-7.23,-.95,;-8.56,-1.72,;-8.56,-3.26,;-9.89,-.95,;-5.89,1.36,;-4.56,.59,;-4.56,-.95,;-3.22,1.36,;-3.22,-.18,;-1.89,-.95,;-.56,-.18,;.78,-.95,;.78,-2.49,;2.11,-3.26,;-.56,-3.26,;-1.89,.59,;-.56,1.36,;.78,.59,;-.56,2.9,;.78,2.13,;2.11,2.9,;2.11,4.44,;3.44,5.21,;4.78,4.44,;6.11,5.21,;4.78,2.9,;3.44,2.13,;.78,3.67,;.78,5.21,;2.11,5.98,;-.56,5.98,;-1.89,5.21,;-3.22,5.98,;-3.22,7.52,;-4.56,5.21,;-5.89,5.98,;-7.23,5.21,;-8.56,5.98,;-10.05,5.2,;-9.38,3.81,;-7.23,6.75,;-5.89,7.52,;-8.56,7.52,;-.56,7.52,;.78,8.29,;.78,9.83,;2.11,7.52,;2.57,6.44,;3.91,4.74,;3.49,3.26,;4.61,2.25,;5.98,3.36,;7.49,3.1,;8.48,4.28,;7.95,5.73,;6.43,5.99,;5.44,4.8,;3.44,8.29,;4.78,7.52,;4.78,5.98,;6.11,8.29,;6.11,9.83,;4.78,10.6,;3.44,9.83,;2.11,10.6,;2.11,12.14,;.78,12.91,;3.44,12.91,;4.78,12.14,;7.44,7.52,;8.78,8.29,;8.78,9.83,;10.11,7.52,;10.11,5.98,;11.45,8.29,;12.78,7.52,;12.78,5.98,;14.11,5.21,;15.45,5.98,;16.78,5.21,;18.11,5.98,;18.11,7.52,;16.78,8.29,;15.45,7.52,;14.11,8.29,)|
Structure:
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