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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50022919
Substrate
n/a
Meas. Tech.
ChEBML_71742
Kd
10±n/a nM
Citation
 Rivier, J; Kupryszewski, G; Varga, J; Porter, J; Rivier, C; Perrin, M; Hagler, A; Struthers, S; Corrigan, A; Vale, W Design of potent cyclic gonadotropin releasing hormone antagonists. J Med Chem 31:677-82 (1988) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50022919
Synonyms:
Ac-DNal-DFpa-DTrp-[Asp-Tyr-DArg-Leu-Arg-Pro-Dpr]-NH2 | CHEMBL2371275
Type:
Small organic molecule
Emp. Form.:
C72H92FN19O12
Mol. Mass.:
1434.6194
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CNC(=O)C[C@H](NC2=O)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](Cc1ccc(F)cc1)NC(=O)[C@H](N)Cc1ccc2ccccc2c1 |wU:80.94,56.62,19.20,92.98,8.9,27.28,wD:50.65,66.81,38.39,1.0,(2.81,9.26,;1.87,10.87,;3.38,11.19,;3.54,12.73,;2.13,13.35,;1.1,12.21,;-.4,11.89,;-.61,10.36,;-1.9,12.67,;-1.93,14.21,;-3.28,14.95,;-3.32,16.49,;-4.67,17.23,;-4.7,18.77,;-6.05,19.51,;-3.38,19.57,;-3.23,11.9,;-3.23,10.36,;-1.9,9.59,;-4.57,9.59,;-5.9,10.36,;-5.9,11.9,;-7.23,12.67,;-4.57,12.67,;-4.57,8.05,;-5.9,7.28,;-7.23,8.05,;-5.9,5.74,;-7.23,6.51,;-8.57,5.74,;-8.57,4.2,;-9.9,3.43,;-11.23,4.2,;-12.57,3.43,;-11.23,5.74,;-7.23,4.97,;-7.23,3.43,;-8.57,2.66,;-5.9,2.66,;-7.23,1.89,;-7.23,.35,;-5.9,-.42,;-5.9,-1.96,;-7.23,-2.73,;-7.23,-4.27,;-8.57,-1.96,;-8.57,-.42,;-5.9,1.12,;-4.57,.35,;-4.57,-1.19,;-3.23,1.12,;-3.23,2.66,;-1.9,3.43,;-1.9,4.97,;-3.23,5.74,;-.57,5.74,;-.57,7.28,;.77,8.05,;.84,9.73,;-.69,9.84,;.77,6.51,;2.1,7.28,;.77,4.97,;-1.9,.35,;-.57,1.12,;-.57,2.66,;.77,.35,;.77,-1.19,;-.57,-1.96,;-1.97,-1.34,;-3,-2.48,;-2.23,-3.82,;-2.71,-5.28,;-1.68,-6.42,;-.17,-6.1,;.3,-4.64,;-.73,-3.49,;2.1,1.12,;3.44,.35,;3.44,-1.19,;4.77,1.12,;4.77,2.66,;6.1,3.43,;6.1,4.97,;7.44,5.74,;8.77,4.97,;10.1,5.74,;8.77,3.43,;7.44,2.66,;6.1,.35,;7.44,1.12,;8.34,2.36,;8.77,.35,;8.77,-1.19,;10.1,1.12,;11.44,.35,;11.44,-1.19,;12.77,-1.96,;14.11,-1.19,;15.44,-1.96,;16.77,-1.19,;16.77,.35,;15.44,1.12,;14.11,.35,;12.77,1.12,)|
Structure:
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