Reaction Details Report a problem with these data
Target
Cyclin-C/Cyclin-dependent kinase 8
Ligand
BDBM62810
Substrate
n/a
Meas. Tech.
ChEMBL_1768134 (CHEMBL4220246)
EC50
1400±n/a nM
Citation
 Philip, S; Kumarasiri, M; Teo, T; Yu, M; Wang, S Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy? J Med Chem 61:5073-5092 (2018) [PubMed]  Article 
Target
Name:
Cyclin-C/Cyclin-dependent kinase 8
Synonyms:
Cyclin-dependent kinase 8/Cyclin-C
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1768134
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 8
Synonyms:
2.7.11.22 | 2.7.11.23 | CDK8_MOUSE | Cdk8 | Cell division protein kinase 8 | Cyclin-dependent kinase 8 | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8
Type:
PROTEIN
Mol. Mass.:
53226.21
Organism:
Mus musculus
Description:
ChEMBL_118299
Residue:
464
Sequence:
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDEKGDKKTQQQQQGNNHTNGTGHPGNQDSGHAQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
  
Component 2
Name:
Cyclin-C
Synonyms:
CCNC_MOUSE | Ccnc | Cyclin-C
Type:
PROTEIN
Mol. Mass.:
33242.84
Organism:
Mus musculus
Description:
ChEMBL_118299
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAATTSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDVLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM62810
Synonyms:
2-amino-6-methyl-4-(3-pyridinyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile | 2-amino-6-methyl-4-(3-pyridyl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile | 2-amino-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydroquinoline-3-carbonitrile | 2-azanyl-6-methyl-4-pyridin-3-yl-5,6,7,8-tetrahydroquinoline-3-carbonitrile | MLS000114823 | SMR000092114 | cid_3835861
Type:
Small organic molecule
Emp. Form.:
C16H16N4
Mol. Mass.:
264.325
SMILES:
CC1CCc2nc(N)c(C#N)c(-c3cccnc3)c2C1
Structure:
Search PDB for entries with ligand similarity: