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Target
Uridine 5'-monophosphate synthase
Ligand
BDBM50459997
Substrate
n/a
Meas. Tech.
ChEMBL_1768165 (CHEMBL4220277)
Ki
17±n/a nM
Citation
 Slusarczyk, M; Ferla, S; Brancale, A; McGuigan, C Synthesis and biological evaluation of 6-substituted-5-fluorouridine ProTides. Bioorg Med Chem 26:551-565 (2018) [PubMed]  Article 
Target
Name:
Uridine 5'-monophosphate synthase
Synonyms:
Orotate phosphoribosyltransferase (HsOPRT) | Orotidine Monophosphate Decarboxylase (ODCase) | UMPS | UMPS_HUMAN
Type:
Enzyme
Mol. Mass.:
52224.99
Organism:
Homo sapiens (Human)
Description:
P11172
Residue:
480
Sequence:
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQTAQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCLIIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKMLEILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVASKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELITLAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLPLHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQLEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
  
Inhibitor
Name:
BDBM50459997
Synonyms:
47599 | CHEBI:90284 | Pirazofurin | Pyrazofurin
Type:
Small organic molecule
Emp. Form.:
C9H13N3O6
Mol. Mass.:
259.216
SMILES:
NC(=O)c1[nH]nc([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)c1O
Structure:
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