Reaction Details Report a problem with these data
Target
ADP-ribose glycohydrolase MACROD1
Ligand
BDBM50460478
Substrate
n/a
Meas. Tech.
ChEBML_1769549
Kd
900±n/a nM
Citation
 Zhang, Y; Jumppanen, M; Maksimainen, MM; Auno, S; Awol, Z; Ghemtio, L; Venkannagari, H; Lehtiö, L; Yli-Kauhaluoma, J; Xhaard, H; Boije Af Gennäs, G Adenosine analogs bearing phosphate isosteres as human MDO1 ligands. Bioorg Med Chem 26:1588-1597 (2018) [PubMed]  Article 
Target
Name:
ADP-ribose glycohydrolase MACROD1
Synonyms:
3.1.1.106 | 3.2.2.- | ADP-ribose glycohydrolase MACROD1 | LRP16 | MACD1_HUMAN | MACRO domain-containing protein 1 | MACROD1 | O-acetyl-ADP-ribose deacetylase MACROD1 | Protein LRP16 | [Protein ADP-ribosylaspartate] hydrolase MACROD1 | [Protein ADP-ribosylglutamate] hydrolase MACROD1
Type:
PROTEIN
Mol. Mass.:
35525.35
Organism:
Homo sapiens
Description:
ChEMBL_118179
Residue:
325
Sequence:
MSLQSRLSGRLAQLRAAGQLLVPPRPRPGHLAGATRTRSSTCGPPAFLGVFGRRARTSAGVGAWGAAAVGRTAGVRTWAPLAMAAKVDLSTSTDWKEAKSFLKGLSDKQREEHYFCKDFVRLKKIPTWKEMAKGVAVKVEEPRYKKDKQLNEKISLLRSDITKLEVDAIVNAANSSLLGGGGVDGCIHRAAGPLLTDECRTLQSCKTGKAKITGGYRLPAKYVIHTVGPIAYGEPSASQAAELRSCYLSSLDLLLEHRLRSVAFPCISTGVFGYPCEAAAEIVLATLREWLEQHKDKVDRLIICVFLEKDEDIYRSRLPHYFPVA
  
Inhibitor
Name:
BDBM50460478
Synonyms:
CHEMBL4226903
Type:
Small organic molecule
Emp. Form.:
C15H23N5O14P2
Mol. Mass.:
559.3157
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@H](O)[C@@H](O)[C@H]2O)[C@@H](O)[C@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: