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Target
Rhomboid protease GluP
Ligand
BDBM50460512
Substrate
n/a
Meas. Tech.
ChEBML_1769602
IC50
4600±n/a nM
Citation
 Yang, J; Barniol-Xicota, M; Nguyen, MTN; Ticha, A; Strisovsky, K; Verhelst, SHL Benzoxazin-4-ones as novel, easily accessible inhibitors for rhomboid proteases. Bioorg Med Chem Lett 28:1423-1427 (2018) [PubMed]  Article 
Target
Name:
Rhomboid protease GluP
Synonyms:
3.4.21.105 | GLUP_BACSU | Intramembrane serine protease | Rhomboid protease GluP | gluP | yqgP | yqgP
Type:
PROTEIN
Mol. Mass.:
56456.50
Organism:
Bacillus subtilis (strain 168)
Description:
ChEMBL_117824
Residue:
507
Sequence:
MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLVRLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKKTFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLKQEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIAQGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIASFVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNIDNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESALIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERAVKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES
  
Inhibitor
Name:
BDBM50460512
Synonyms:
CHEMBL4225312
Type:
Small organic molecule
Emp. Form.:
C16H13NO3
Mol. Mass.:
267.2793
SMILES:
Cc1ccc2nc(OCc3ccccc3)oc(=O)c2c1
Structure:
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