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Target
LgtC
Ligand
BDBM50461213
Substrate
n/a
Meas. Tech.
ChEMBL_1770912 (CHEMBL4223024)
Ki
19000±n/a nM
Citation
 Xu, Y; Cuccui, J; Denman, C; Maharjan, T; Wren, BW; Wagner, GK Structure-activity relationships in a new class of non-substrate-like covalent inhibitors of the bacterial glycosyltransferase LgtC. Bioorg Med Chem 26:2973-2983 (2018) [PubMed]  Article 
Target
Name:
LgtC
Synonyms:
LgtC
Type:
PROTEIN
Mol. Mass.:
35743.49
Organism:
Neisseria meningitidis
Description:
ChEMBL_118164
Residue:
311
Sequence:
MDIVFAADDNYAAYLCVAAKSVEAAHPDTEIRFHVLDAGISEANRAAVAANLRGGGGNIRFIDVNPEDFAGFPLNIRHISITTYARLKLGEYIADCDKVLYLDIDVLVRDSLTPLWDTDLGDNWLGACIDLFVERQEGYKQKIGMADGEYYFNAGVLLINLKKWRRHDIFKMSCEWVEQYKDVMQYQDQDILNGLFKGGVCYANSRFNFMPTNYAFMANRFASRHTDPLYRDRTNTVMPVAVSHYCGPAKPWHRDCTAWGAERFTELAGSLTTVPEEWRGKLAVPHRMFSTKRMLQRWRRKLSARFLRKIY
  
Inhibitor
Name:
BDBM50461213
Synonyms:
CHEMBL4226211
Type:
Small organic molecule
Emp. Form.:
C18H13F3N2O2
Mol. Mass.:
346.3032
SMILES:
COc1ccc(\C=C2/C(=O)N(N=C2C(F)(F)F)c2ccccc2)cc1 |c:11|
Structure:
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