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Target
Neutrophil elastase
Ligand
BDBM50023568
Substrate
n/a
Meas. Tech.
ChEBML_63669
IC50
1500±n/a nM
Citation
 Miyano, M; Deason, JR; Nakao, A; Stealey, MA; Villamil, CI; Sohn, DD; Mueller, RA (Acyloxy)benzophenones and (acyloxy)-4-pyrones. A new class of inhibitors of human neutrophil elastase. J Med Chem 31:1052-61 (1988) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50023568
Synonyms:
2,2-Dimethyl-propionic acid 4-{[4-(2,2-dimethyl-propionyloxy)-phenyl]-hydroxy-methyl}-phenyl ester | CHEMBL10529
Type:
Small organic molecule
Emp. Form.:
C23H28O5
Mol. Mass.:
384.4654
SMILES:
CC(C)(C)C(=O)Oc1ccc(cc1)C(O)c1ccc(OC(=O)C(C)(C)C)cc1
Structure:
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