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Target
Mitogen-activated protein kinase 1
Ligand
BDBM103297
Substrate
n/a
Meas. Tech.
ChEMBL_1772222 (CHEMBL4224334)
IC50
7.0±n/a nM
Citation
 Boga, SB; Alhassan, AB; Cooper, AB; Doll, R; Shih, NY; Shipps, G; Deng, Y; Zhu, H; Nan, Y; Sun, R; Zhu, L; Desai, J; Patel, M; Muppalla, K; Gao, X; Wang, J; Yao, X; Kelly, J; Gudipati, S; Paliwal, S; Tsui, HC; Wang, T; Sherborne, B; Xiao, L; Hruza, A; Buevich, A; Zhang, LK; Hesk, D; Samatar, AA; Carr, D; Long, B; Black, S; Dayananth, P; Windsor, W; Kirschmeier, P; Bishop, R Discovery of 3(S)-thiomethyl pyrrolidine ERK inhibitors for oncology. Bioorg Med Chem Lett 28:2029-2034 (2018) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 1
Synonyms:
ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:
Ser/Thr Protein Kinase
Mol. Mass.:
41392.76
Organism:
Homo sapiens (Human)
Description:
P28482
Residue:
360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
  
Inhibitor
Name:
BDBM103297
Synonyms:
US8546404, 613
Type:
Small organic molecule
Emp. Form.:
C36H34FN7O2S
Mol. Mass.:
647.764
SMILES:
CS[C@]1(CCN(CC(=O)N2CCC(=CC2)c2ccc(cc2)-c2ncccn2)C1)C(=O)Nc1ccc2[nH]nc(-c3ccc(F)cc3)c2c1 |r,c:12|
Structure:
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