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Target
D(2) dopamine receptor
Ligand
BDBM50462136
Substrate
n/a
Meas. Tech.
ChEMBL_1772846 (CHEMBL4229838)
Ki
8.0±n/a nM
Citation
 Zajdel, P; Kos, T; Marciniec, K; Sata?a, G; Canale, V; Kami?ski, K; Ho?uj, M; Lenda, T; Koralewski, R; Bednarski, M; Nowi?ski, L; Wójcikowski, J; Daniel, WA; Nikiforuk, A; Nalepa, I; Chmielarz, P; Ku?mierczyk, J; Bojarski, AJ; Popik, P Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects. Eur J Med Chem 145:790-804 (2018) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50462136
Synonyms:
CHEMBL4248597
Type:
Small organic molecule
Emp. Form.:
C27H31N5O2S
Mol. Mass.:
489.632
SMILES:
O=S(=O)(N1CCC[C@@H]1CCN1CCN(CC1)c1cccc2[nH]ccc12)c1cccc2ncccc12 |r|
Structure:
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