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Target
Polyphenol oxidase 2
Ligand
BDBM50462585
Substrate
n/a
Meas. Tech.
ChEMBL_1775707 (CHEMBL4232699)
IC50
32080±n/a nM
Citation
 Kim, SJ; Yang, J; Lee, S; Park, C; Kang, D; Akter, J; Ullah, S; Kim, YJ; Chun, P; Moon, HR The tyrosinase inhibitory effects of isoxazolone derivatives with a (Z)-?-phenyl-?, ?-unsaturated carbonyl scaffold. Bioorg Med Chem 26:3882-3889 (2018) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50462585
Synonyms:
CHEMBL4246390
Type:
Small organic molecule
Emp. Form.:
C16H11NO4
Mol. Mass.:
281.2628
SMILES:
Oc1ccc(\C=C2/C(=O)ON=C2c2ccccc2)c(O)c1 |c:10|
Structure:
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