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Target
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Ligand
BDBM26179
Substrate
n/a
Meas. Tech.
ChEMBL_1776145 (CHEMBL4233137)
IC50
2440±n/a nM
Citation
 Platzer, C; Najjar, A; Rohe, A; Erdmann, F; Sippl, W; Schmidt, M Identification of PKMYT1 inhibitors by screening the GSK published protein kinase inhibitor set I and II. Bioorg Med Chem 26:4014-4024 (2018) [PubMed]  Article 
Target
Name:
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase
Synonyms:
MYT1 | PKMYT1 | PMYT1_HUMAN | Tyrosine- and threonine-specific cdc2-inhibitory kinase
Type:
PROTEIN
Mol. Mass.:
54523.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_587209
Residue:
499
Sequence:
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT
  
Inhibitor
Name:
BDBM26179
Synonyms:
2,4-dianilino pyrimidine, 36 | 3-{[4-(1H-indazol-4-ylamino)pyrimidin-2-yl]amino}benzamide | GTC000110A
Type:
Small organic molecule
Emp. Form.:
C18H15N7O
Mol. Mass.:
345.358
SMILES:
NC(=O)c1cccc(Nc2nccc(Nc3cccc4[nH]ncc34)n2)c1
Structure:
Search PDB for entries with ligand similarity: