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Target
2-Hydroxyacid oxidase 1
Ligand
BDBM50463046
Substrate
n/a
Meas. Tech.
ChEMBL_1777435 (CHEMBL4234427)
Ki
15±n/a nM
Citation
 Moya-Garzón, MD; Martín Higueras, C; Peñalver, P; Romera, M; Fernandes, MX; Franco-Montalbán, F; Gómez-Vidal, JA; Salido, E; Díaz-Gavilán, M Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1. J Med Chem 61:7144-7167 (2018) [PubMed]  Article 
Target
Name:
2-Hydroxyacid oxidase 1
Synonyms:
GOX1 | HAO1 | HAOX1_HUMAN | Hydroxyacid oxidase 1
Type:
PROTEIN
Mol. Mass.:
40927.89
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71275
Residue:
370
Sequence:
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
  
Inhibitor
Name:
BDBM50463046
Synonyms:
CHEMBL1229989
Type:
Small organic molecule
Emp. Form.:
C15H27N3O2S
Mol. Mass.:
313.459
SMILES:
CCCCCCCCCCCCSc1[nH]nnc1C(O)=O
Structure:
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