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Target
5'-AMP-activated protein kinase subunit gamma-1
Ligand
BDBM50463099
Substrate
n/a
Meas. Tech.
ChEMBL_1777649 (CHEMBL4234641)
EC50
>40000±n/a nM
Citation
 Ryder, TF; Calabrese, MF; Walker, GS; Cameron, KO; Reyes, AR; Borzilleri, KA; Delmore, J; Miller, R; Kurumbail, RG; Ward, J; Kung, DW; Brown, JA; Edmonds, DJ; Eng, H; Wolford, AC; Kalgutkar, AS Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem 61:7273-7288 (2018) [PubMed]  Article 
Target
Name:
5'-AMP-activated protein kinase subunit gamma-1
Synonyms:
5'-AMP-activated protein kinase subunit gamma-1 | AAKG1_HUMAN | AMP-activated protein kinase, gamma-1 subunit | AMPK alpha2/beta2/gamma1 | AMPK gamma-1 | AMPK gamma1 | AMPK subunit gamma-1 | AMPKg | PRKAG1
Type:
n/a
Mol. Mass.:
37581.44
Organism:
Homo sapiens (Human)
Description:
P54619
Residue:
331
Sequence:
METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP
  
Inhibitor
Name:
BDBM50463099
Synonyms:
CHEMBL4246000
Type:
Small organic molecule
Emp. Form.:
C26H25F2NO9
Mol. Mass.:
533.4748
SMILES:
O[C@@H]1[C@@H](O)[C@H](OC(=O)c2c[nH]c3cc(F)c(c(F)c23)-c2ccc(cc2)[C@@H]2CCCCO2)O[C@@H]([C@H]1O)C(O)=O |r|
Structure:
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