Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 6
Ligand
BDBM50463592
Substrate
n/a
Meas. Tech.
ChEMBL_1778809 (CHEMBL4235801)
IC50
280±n/a nM
Citation
 Tawaraishi, T; Sakauchi, N; Hidaka, K; Yoshikawa, K; Okui, T; Kuno, H; Chisaki, I; Aso, K Identification of a novel series of potent and selective CCR6 inhibitors as biological probes. Bioorg Med Chem Lett 28:3067-3072 (2018) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 6
Synonyms:
C-C chemokine receptor type 6 | CCR6
Type:
PROTEIN
Mol. Mass.:
42673.20
Organism:
Macaca mulatta
Description:
ChEMBL_117797
Residue:
374
Sequence:
MSGESMNFSDVFDSSEDYFASVNTSYYTVDSEMLLCTLHEVRQFSRLFVPIAYSLICVFGLLGNILVVITFAFYKKARSMTDVYLLNMAIADILFVLTLPFWAVSHATGAWVFSNAMCKLMKGIYAINFNCGMLLLTCISMDRYIAIVQATKSFRLRYRTLLRSKVICLIVWGVSVVISSSTFIFNQKYNIQGSDVCEPKYQTVSEPIKWKLLMLGLELLFGFFIPLMFMIFCYMFIVKTLVQAQNSKRHKAIRVIIAVVLVFLACQIPHNMVLLVTAANLGNMNRSCHSEKLLGYTKTVTEVLAFLHCCLNPVLYAFIGQKFRNYFLKIMKDLWCVRRKYKSSGFSCAGRYSENISRQTSETADNDNASSFTM
  
Inhibitor
Name:
BDBM50463592
Synonyms:
CHEMBL4245036
Type:
Small organic molecule
Emp. Form.:
C23H22N4O2S
Mol. Mass.:
418.511
SMILES:
O=S(=O)(N1CCC(CC1)Nc1ccc(cn1)C#N)c1ccc(cc1)-c1ccccc1
Structure:
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