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Target
Protein-lysine 6-oxidase
Ligand
BDBM50058655
Substrate
n/a
Meas. Tech.
ChEMBL_1778827 (CHEMBL4235819)
IC50
320±n/a nM
Citation
 Hajdú, I; Kardos, J; Major, B; Fabó, G; Lőrincz, Z; Cseh, S; Dormán, G Inhibition of the LOX enzyme family members with old and new ligands. Selectivity analysis revisited. Bioorg Med Chem Lett 28:3113-3118 (2018) [PubMed]  Article 
Target
Name:
Protein-lysine 6-oxidase
Synonyms:
LYOX_HUMAN | LOX | Lysyl oxidase | alpha-Glucosidase (alpha-Glu)
Type:
PROTEIN
Mol. Mass.:
46954.13
Organism:
Human
Description:
ChEMBL_306619
Residue:
417
Sequence:
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
  
Inhibitor
Name:
BDBM50058655
Synonyms:
1,1',1'',1'''-[disulfanediylbis(carbonothioylnitrilo)]tetraethane | 1,1'-dithiobis(N,N-diethylthioformamide) | Antabuse (TN) | CHEMBL964 | N,N,N',N'-tetraethylthiuram disulfide | bis(diethylthiocarbamoyl) disulfide | tetraethylthioperoxydicarbonic diamide | tetraethylthiuram disulfide | tetraethylthiuram disulphide | DISULFIRAM | N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide (G5) | cid_3117 | med.21724, Compound 151 | Disul-firam | US11753371, Compound II-2a-(Disulfiram) | US20230414581, Compound 37 | US20250145565, Compound Disulfiram
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CCN(CC)C(=S)SSC(=S)N(CC)CC
Structure:
Search PDB for entries with ligand similarity: