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Target
Intestinal-type alkaline phosphatase
Ligand
BDBM50464740
Substrate
n/a
Meas. Tech.
ChEMBL_1782194 (CHEMBL4253711)
IC50
1670±n/a nM
Citation
 Jafari, B; Ospanov, M; Ejaz, SA; Yelibayeva, N; Khan, SU; Amjad, ST; Safarov, S; Abilov, ZA; Turmukhanova, MZ; Kalugin, SN; Ehlers, P; Lecka, J; Sévigny, J; Iqbal, J; Langer, P 2-Substituted 7-trifluoromethyl-thiadiazolopyrimidones as alkaline phosphatase inhibitors. Synthesis, structure activity relationship and molecular docking study. Eur J Med Chem 144:116-127 (2018) [PubMed]  Article 
Target
Name:
Intestinal-type alkaline phosphatase
Synonyms:
ALPI | Alkaline phosphatase, intestinal | Intestinal alkaline phosphatase | PPBI_HUMAN
Type:
PROTEIN
Mol. Mass.:
56804.94
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1278525
Residue:
528
Sequence:
MQGPWVLLLLGLRLQLSLGVIPAEEENPAFWNRQAAEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATRILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARFNQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGCQDIATQLISNMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEWLAKHQGAWYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPTLDPSLMEMTEAALRLLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVFSFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPGYVFNSGVRPDVNESESGSPDYQQQAAVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPYTACDLAPPACTTDAAHPVAASLPLLAGTLLLLGASAAP
  
Inhibitor
Name:
BDBM50464740
Synonyms:
CHEMBL4284091
Type:
Small organic molecule
Emp. Form.:
C18H10F3N3OS
Mol. Mass.:
373.352
SMILES:
FC(F)(F)c1cc(=O)n2nc(sc2n1)-c1cccc(c1)-c1ccccc1
Structure:
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