Reaction Details Report a problem with these data
Target
4-aminobutyrate aminotransferase, mitochondrial
Ligand
BDBM50024970
Substrate
n/a
Meas. Tech.
ChEBML_70673
Ki
5000±n/a nM
Citation
 Silverman, RB; Durkee, SC; Invergo, BJ 4-Amino-2-(substituted methyl)-2-butenoic acids: substrates and potent inhibitors of gamma-aminobutyric acid aminotransferase. J Med Chem 29:764-70 (1986) [PubMed]  Article 
Target
Name:
4-aminobutyrate aminotransferase, mitochondrial
Synonyms:
(S)-3-amino-2-methylpropionate transaminase | 2.6.1.19 | 2.6.1.22 | 4-aminobutyrate aminotransferase, mitochondrial | ABAT | GABA aminotransferase | GABA transaminase | GABA-AT | GABA-T | GABAT | GABT_PIG | Gamma-amino-N-butyrate transaminase | L-AIBAT
Type:
n/a
Mol. Mass.:
56633.06
Organism:
Sus scrofa
Description:
n/a
Residue:
500
Sequence:
MASVLLTRRLACSFRHNHRLLVPGWRHISQAAAKVDVEFDYDGPLMKTEVPGPRSRELMKQLNIIQNAEAVHFFCNYEESRGNYLVDVDGNRMLDLYSQISSIPIGYSHPALVKLVQQPQNVSTFINRPALGILPPENFVEKLRESLLSVAPKGMSQLITMACGSCSNENAFKTIFMWYRSKERGQSAFSKEELETCMINQAPGCPDYSILSFMGAFHGRTMGCLATTHSKAIHKIDIPSFDWPIAPFPRLKYPLEEFVKENQQEEARCLEEVEDLIVKYRKKKKTVAGIIVEPIQSEGGDNHASDDFFRKLRDISRKHGCAFLVDEVQTGGGSTGKFWAHEHWGLDDPADVMTFSKKMMTGGFFHKEEFRPNAPYRIFNTWLGDPSKNLLLAEVINIIKREDLLSNAAHAGKVLLTGLLDLQARYPQFISRVRGRGTFCSFDTPDESIRNKLISIARNKGVMLGGCGDKSIRFRPTLVFRDHHAHLFLNIFSDILADFK
  
Inhibitor
Name:
BDBM50024970
Synonyms:
(2E)-4-ammonio-2-(hydroxymethyl)but-2-enoate | CHEMBL349501
Type:
Small organic molecule
Emp. Form.:
C5H9NO3
Mol. Mass.:
131.1299
SMILES:
[NH3+]C\C=C(/CO)C([O-])=O
Structure:
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