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Target
Presenilin-1
Ligand
BDBM50465363
Substrate
n/a
Meas. Tech.
ChEMBL_1784703 (CHEMBL4256220)
EC50
13±n/a nM
Citation
 Blass, BE Azabicyclic Fused Pyrimidine Derivatives Useful for the Treatment of Alzheimer's Disease. ACS Med Chem Lett 9:290-291 (2018) [PubMed]  Article 
Target
Name:
Presenilin-1
Synonyms:
3.4.23.- | AD3 | Gamma-Secretase Subunit Presenilin-1 | PS-1 | PS1 | PS1-CTF12 | PSEN1 | PSN1_HUMAN | PSNL1 | Presenilin-1 CTF subunit | Presenilin-1 CTF12 | Presenilin-1 NTF subunit | Protein S182
Type:
n/a
Mol. Mass.:
52657.13
Organism:
Homo sapiens (Human)
Description:
P49768
Residue:
467
Sequence:
MTELPAPLSYFQNAQMSEDNHLSNTVRSQNDNRERQEHNDRRSLGHPEPLSNGRPQGNSRQVVEQDEEEDEELTLKYGAKHVIMLFVPVTLCMVVVVATIKSVSFYTRKDGQLIYTPFTEDTETVGQRALHSILNAAIMISVIVVMTILLVVLYKYRCYKVIHAWLIISSLLLLFFFSFIYLGEVFKTYNVAVDYITVALLIWNFGVVGMISIHWKGPLRLQQAYLIMISALMALVFIKYLPEWTAWLILAVISVYDLVAVLCPKGPLRMLVETAQERNETLFPALIYSSTMVWLVNMAEGDPEAQRRVSKNSKYNAESTERESQDTVAENDDGGFSEEWEAQRDSHLGPHRSTPESRAAVQELSSSILAGEDPEERGVKLGLGDFIFYSVLVGKASATASGDWNTTIACFVAILIGLCLTLLLLAIFKKALPALPISITFGLVFYFATDYLVQPFMDQLAFHQFYI
  
Inhibitor
Name:
BDBM50465363
Synonyms:
CHEMBL4278310 | US10669276, Example 35
Type:
Small organic molecule
Emp. Form.:
C26H29FN8O
Mol. Mass.:
488.5599
SMILES:
CNc1nc(Nc2ccc(c(OC)c2)-n2cnc(C)n2)nc2N(CCC(C)(C)c12)c1ccc(F)cc1
Structure:
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