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Target
S-adenosylmethionine synthase isoform type-1/type-2
Ligand
BDBM50025157
Substrate
n/a
Meas. Tech.
ChEMBL_104810 (CHEMBL709695)
Ki
2400000±n/a nM
Citation
 Lim, H; Kappler, F; Hai, TT; Hampton, A Isozyme-specific enzyme inhibitors. 12. C- and N-methylmethionines as substrates and inhibitors of methionine adenosyltransferases of normal and hepatoma rat tissues. J Med Chem 29:1743-8 (1986) [PubMed]  Article 
Target
Name:
S-adenosylmethionine synthase isoform type-1/type-2
Synonyms:
S-adenosylmethionine synthetase (MAT 1 and MAT 2)
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 104961
Components:
This complex has 2 components.
Component 1
Name:
S-adenosylmethionine synthase isoform type-1
Synonyms:
AdoMet synthetase 1 | Ams1 | MAT 1 | MAT-I/III | METK1_RAT | Mat1a | Methionine adenosyltransferase 1 | Methionine adenosyltransferase I/III | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase alpha and beta forms | S-adenosylmethionine synthetase isoform type-1
Type:
PROTEIN
Mol. Mass.:
43692.87
Organism:
Rattus norvegicus
Description:
ChEMBL_11027
Residue:
397
Sequence:
MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
  
Component 2
Name:
S-adenosylmethionine synthase isoform type-2
Synonyms:
AdoMet synthetase 2 | Ams2 | MAT 2 | MAT-II | METK2_RAT | Mat2a | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-Adenosylmethionine Synthase (AdoMet) | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2
Type:
PROTEIN
Mol. Mass.:
43713.68
Organism:
Rattus norvegicus
Description:
ChEMBL_105118
Residue:
395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVAKTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQGVHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDSKTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVIVRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
  
Inhibitor
Name:
BDBM50025157
Synonyms:
2-Amino-2-methyl-4-methylsulfanyl-pentanoic acid | CHEMBL45647
Type:
Small organic molecule
Emp. Form.:
C7H15NO2S
Mol. Mass.:
177.265
SMILES:
CS[C@@H](C)C[C@](C)(N)C(O)=O
Structure:
Search PDB for entries with ligand similarity: