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Target
WD repeat-containing protein 5
Ligand
BDBM49419
Substrate
n/a
Meas. Tech.
ChEMBL_1785273 (CHEMBL4256790)
Ki
8440±n/a nM
Citation
 Wang, F; Jeon, KO; Salovich, JM; Macdonald, JD; Alvarado, J; Gogliotti, RD; Phan, J; Olejniczak, ET; Sun, Q; Wang, S; Camper, D; Yuh, JP; Shaw, JG; Sai, J; Rossanese, OW; Tansey, WP; Stauffer, SR; Fesik, SW Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design. J Med Chem 61:5623-5642 (2018) [PubMed]  Article 
Target
Name:
WD repeat-containing protein 5
Synonyms:
BIG3 | WD repeat-containing protein 5 | WD repeat-containing protein 5 (WDR5) | WD repeat-containing protein 5 (WRD5) | WDR5 | WDR5_HUMAN
Type:
Protein
Mol. Mass.:
36597.13
Organism:
Homo sapiens (Human)
Description:
P61964
Residue:
334
Sequence:
MATEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLWKSDC
  
Inhibitor
Name:
BDBM49419
Synonyms:
2-(4-phenylphenyl)-6,7-dihydro-5H-pyrrol[1,2-a]imidazole;hydrobromide | 2-(4-phenylphenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole;hydrobromide | 2-Biphenyl-4-yl-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole | MLS000552669 | SMR000146184 | cid_9550136
Type:
Small organic molecule
Emp. Form.:
C18H16N2
Mol. Mass.:
260.333
SMILES:
C1Cc2nc(cn2C1)-c1ccc(cc1)-c1ccccc1
Structure:
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