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Target
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
Ligand
BDBM50465805
Substrate
n/a
Meas. Tech.
ChEMBL_1788860 (CHEMBL4260594)
IC50
54000±n/a nM
Citation
 Muthukaman, N; Deshmukh, S; Tondlekar, S; Tambe, M; Pisal, D; Sarode, N; Mhatre, S; Chakraborti, S; Shah, D; Bhosale, VM; Kulkarni, A; Mahat, MYA; Jadhav, SB; Gudi, GS; Khairatkar-Joshi, N; Gharat, LA Discovery of 5-(2-chloro-4'-(1H-imidazol-1-yl)-[1,1'-biphenyl]-4-yl)-1H-tetrazole as potent and orally efficacious S-nitrosoglutathione reductase (GSNOR) inhibitors for the potential treatment of COPD. Bioorg Med Chem Lett 28:3766-3773 (2018) [PubMed]  Article 
Target
Name:
All-trans-retinol dehydrogenase [NAD(+)] ADH1B
Synonyms:
ADH1B | ADH1B_HUMAN | ADH2 | Alcohol dehydrogenase | Alcohol dehydrogenase beta chain
Type:
PROTEIN
Mol. Mass.:
39864.68
Organism:
Homo sapiens (Human)
Description:
ChEMBL_31169
Residue:
375
Sequence:
MSTAGKVIKCKAAVLWEVKKPFSIEDVEVAPPKAYEVRIKMVAVGICRTDDHVVSGNLVTPLPVILGHEAAGIVESVGEGVTTVKPGDKVIPLFTPQCGKCRVCKNPESNYCLKNDLGNPRGTLQDGTRRFTCRGKPIHHFLGTSTFSQYTVVDENAVAKIDAASPLEKVCLIGCGFSTGYGSAVNVAKVTPGSTCAVFGLGGVGLSAVMGCKAAGAARIIAVDINKDKFAKAKELGATECINPQDYKKPIQEVLKEMTDGGVDFSFEVIGRLDTMMASLLCCHEACGTSVIVGVPPASQNLSINPMLLLTGRTWKGAVYGGFKSKEGIPKLVADFMAKKFSLDALITHVLPFEKINEGFDLLHSGKSIRTVLTF
  
Inhibitor
Name:
BDBM50465805
Synonyms:
CHEMBL4290485
Type:
Small organic molecule
Emp. Form.:
C16H11ClN6
Mol. Mass.:
322.752
SMILES:
Clc1cc(ccc1-c1ccc(cc1)-n1ccnc1)-c1nnn[nH]1
Structure:
Search PDB for entries with ligand similarity: