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Target
Sialidase A
Ligand
BDBM50466474
Substrate
n/a
Meas. Tech.
ChEMBL_1793220 (CHEMBL4265139)
IC50
100000±n/a nM
Citation
 Slack, TJ; Li, W; Shi, D; McArthur, JB; Zhao, G; Li, Y; Xiao, A; Khedri, Z; Yu, H; Liu, Y; Chen, X Triazole-linked transition state analogs as selective inhibitors against V. cholerae sialidase. Bioorg Med Chem 26:5751-5757 (2018) [PubMed]  Article 
Target
Name:
Sialidase A
Synonyms:
NANA_STREE | Neuraminidase A (NanA) | Sialidase A | nanA
Type:
Enzyme
Mol. Mass.:
114737.08
Organism:
Streptococcus pneumoniae
Description:
P62576; spr1536
Residue:
1035
Sequence:
MSYFRNRDIDIERNSMNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVRLYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRIIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWDFLSKDLISPTEAKVKRTREMGKGVIGLEFDSEVLVNKAPTLQLANGKTARFMTQYDTKTLLFTVDSEDMGQKVTGLAEGAIESMHNLPVSVAGTKLSNGMNGSEAAVHEVPEYTGPLGTSGEEPAPTVEKPEYTGPLGTSGEEPAPTVEKPEYTGPLGTAGEEAAPTVEKPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ
  
Inhibitor
Name:
BDBM50466474
Synonyms:
CHEMBL4282280
Type:
Small organic molecule
Emp. Form.:
C16H23N5O9
Mol. Mass.:
429.3819
SMILES:
[H][C@]1(OC(=C[C@H](O)[C@H]1NC(C)=O)C(O)=O)[C@H](O)[C@H](O)Cn1cc(C[C@H](N)C(O)=O)nn1 |r,c:3|
Structure:
Search PDB for entries with ligand similarity: