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Target
Low molecular weight protein-tyrosine phosphatase A
Ligand
BDBM50466481
Substrate
n/a
Meas. Tech.
ChEMBL_1793230 (CHEMBL4265149)
IC50
18200±n/a nM
Citation
 Sens, L; de Souza, ACA; Pacheco, LA; Menegatti, ACO; Mori, M; Mascarello, A; Nunes, RJ; Terenzi, H Synthetic thiosemicarbazones as a new class of Mycobacterium tuberculosis protein tyrosine phosphatase A inhibitors. Bioorg Med Chem 26:5742-5750 (2018) [PubMed]  Article 
Target
Name:
Low molecular weight protein-tyrosine phosphatase A
Synonyms:
PTPA_MYCTU | PTPase | Probable low molecular weight protein-tyrosine-phosphatase | Protein Tyrosine Phosphatase PTPA | mptpA | ptpA
Type:
Hydrolase
Mol. Mass.:
17891.84
Organism:
Mycobacterium tuberculosis
Description:
n/a
Residue:
163
Sequence:
MSDPLHVTFVCTGNICRSPMAEKMFAQQLRHRGLGDAVRVTSAGTGNWHVGSCADERAAGVLRAHGYPTDHRAAQVGTEHLAADLLVALDRNHARLLRQLGVEAARVRMLRSFDPRSGTHALDVEDPYYGDHSDFEEVFAVIESALPGLHDWVDERLARNGPS
  
Inhibitor
Name:
BDBM50466481
Synonyms:
CHEMBL4285399
Type:
Small organic molecule
Emp. Form.:
C20H19N3O2S
Mol. Mass.:
365.449
SMILES:
COc1ccc(\C=N\NC(=S)Nc2cccc3ccccc23)cc1OC
Structure:
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