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Target
Protein ENL
Ligand
BDBM50466620
Substrate
n/a
Meas. Tech.
ChEMBL_1793461 (CHEMBL4265380)
Kd
800±n/a nM
Citation
 Heidenreich, D; Moustakim, M; Schmidt, J; Merk, D; Brennan, PE; Fedorov, O; Chaikuad, A; Knapp, S Structure-Based Approach toward Identification of Inhibitory Fragments for Eleven-Nineteen-Leukemia Protein (ENL). J Med Chem 61:10929-10934 (2018) [PubMed]  Article 
Target
Name:
Protein ENL
Synonyms:
ENL | ENL_HUMAN | LTG19 | MLLT1 | Protein ENL | YEATS domain-containing protein 1 | YEATS1
Type:
PROTEIN
Mol. Mass.:
62068.50
Organism:
Homo sapiens
Description:
ChEMBL_118046
Residue:
559
Sequence:
MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLEAVAT
  
Inhibitor
Name:
BDBM50466620
Synonyms:
CHEMBL4283481
Type:
Small organic molecule
Emp. Form.:
C21H23IN4O
Mol. Mass.:
474.338
SMILES:
Cc1ccc(cc1I)C(=O)Nc1ccc2[nH]c(CN3CCCCC3)nc2c1
Structure:
Search PDB for entries with ligand similarity: