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Target
Retinal dehydrogenase 2
Ligand
BDBM50459608
Substrate
n/a
Meas. Tech.
ChEMBL_1793494 (CHEMBL4265413)
EC50
44±n/a nM
Citation
 Harper, AR; Le, AT; Mather, T; Burgett, A; Berry, W; Summers, JA Design, synthesis, and ex vivo evaluation of a selective inhibitor for retinaldehyde dehydrogenase enzymes. Bioorg Med Chem 26:5766-5779 (2018) [PubMed]  Article 
Target
Name:
Retinal dehydrogenase 2
Synonyms:
1.2.1.36 | AL1A2_CHICK | ALDH1A2 | Aldehyde dehydrogenase family 1 member A2 | RALDH 2 | RALDH(II) | RALDH2 | Retinal dehydrogenase 2 | Retinaldehyde-specific dehydrogenase type 2
Type:
PROTEIN
Mol. Mass.:
56729.31
Organism:
Gallus gallus
Description:
ChEMBL_117928
Residue:
518
Sequence:
MTSSKIEMPGEVKADPAALMASLHLLPSPTLNLEIKHTKIFINNEWQNSESGRVFPVYNPATGEQICEIQEADKVDTDKAVRAARLAFSLGSVWRRMDASERGQLLDKLADLVERDRAVLATMESLNSGKPFLQAFYVDLQGVIKTLRYYAGWADKIHGMTIPVDGDYFTFTRHEPIGVCGQIIPWNFPLLMFAWKIAPALCCGNTVVIKPAEQTPLSALYMGALIKEAGFPPGVVNILPGFGPIVGAAIASHVGIDKIAFTGSTEVGKLIQEAAGRSNLKRVTLELGGKSPNIIFADADLDYAVEQAHQGVFFNQGQCCTAGSRIYVEESIYEEFVRRSVERAKRRVVGSPFDPTTEQGPQIDKKQYNKILELIQSGITEGAKLECGGKGLGRKGFFIEPTVFSNVTDDMRIAKEEIFGPVQEILRFKTVDEVIERANNSDFGLVAAVFTNDINKALTVSSAMQAGTVWINCYNALNAQSPFGGFKMSGNGREMGESGLREYSEVKTVTIKIPQKNS
  
Inhibitor
Name:
BDBM50459608
Synonyms:
CHEBI:90441 | CHEMBL3276621
Type:
Small organic molecule
Emp. Form.:
C12H20Cl4N2O2
Mol. Mass.:
366.111
SMILES:
ClC(Cl)C(=O)NCCCCCCCCNC(=O)C(Cl)Cl
Structure:
Search PDB for entries with ligand similarity: