Reaction Details Report a problem with these data
Target
Mitochondrial pyruvate carrier 2
Ligand
BDBM228129
Substrate
n/a
Meas. Tech.
ChEMBL_1793755 (CHEMBL4265674)
IC50
1200±n/a nM
Citation
 Tanis, SP; Colca, JR; Parker, TT; Artman, GD; Larsen, SD; McDonald, WG; Gadwood, RC; Kletzien, RF; Zeller, JB; Lee, PH; Adams, WJ PPAR?-sparing thiazolidinediones as insulin sensitizers. Design, synthesis and selection of compounds for clinical development. Bioorg Med Chem 26:5870-5884 (2018) [PubMed]  Article 
Target
Name:
Mitochondrial pyruvate carrier 2
Synonyms:
BRP44 | Brain protein 44 | MPC2 | MPC2_HUMAN | Mitochondrial pyruvate carrier 2
Type:
PROTEIN
Mol. Mass.:
14291.32
Organism:
Homo sapiens
Description:
ChEMBL_117931
Residue:
127
Sequence:
MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK
  
Inhibitor
Name:
BDBM228129
Synonyms:
US9562012, mitoglitazone
Type:
Small organic molecule
Emp. Form.:
C19H18N2O4S
Mol. Mass.:
370.422
SMILES:
CCc1ccc(nc1)C(=O)COc1ccc(CC2SC(=O)NC2=O)cc1
Structure:
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