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Target
Casein kinase II subunit alpha 3
Ligand
BDBM50335638
Substrate
n/a
Meas. Tech.
ChEMBL_1794555 (CHEMBL4266672)
IC50
3.0±n/a nM
Citation
 Jarhad, DB; Mashelkar, KK; Kim, HR; Noh, M; Jeong, LS Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A) Inhibitors as Potential Therapeutics. J Med Chem 61:9791-9810 (2018) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha 3
Synonyms:
2.7.11.1 | CK II alpha 3 | CSK23_HUMAN | CSNK2A1P | CSNK2A3 | Casein kinase II alpha 1 polypeptide pseudogene | Casein kinase II subunit alpha 3
Type:
PROTEIN
Mol. Mass.:
45229.76
Organism:
Homo sapiens
Description:
ChEMBL_116899
Residue:
391
Sequence:
MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWRLGCMLASMIFRKEPFFHGRDNYDQLVRIAKFLGTEDLYGYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANVMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAATGAQQ
  
Inhibitor
Name:
BDBM50335638
Synonyms:
5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid | 5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine-8-carboxylic acid | CHEMBL1230165 | US8168651, Compound TABLE 16.17 | US9062043, Table 13, Compound 17 | US9062043, Table 20b, Compound 12
Type:
Small organic molecule
Emp. Form.:
C19H12ClN3O2
Mol. Mass.:
349.77
SMILES:
OC(=O)c1ccc2c(c1)nc(Nc1cccc(Cl)c1)c1ccncc21
Structure:
Search PDB for entries with ligand similarity: