Reaction Details Report a problem with these data
Target
Dihydropteridine reductase
Ligand
BDBM50025879
Substrate
n/a
Meas. Tech.
ChEMBL_50919 (CHEMBL876701)
Ki
2800±n/a nM
Citation
 Gessner, W; Brossi, A; Shen, R; Abell, CW Synthesis and dihydropteridine reductase inhibitory effects of potential metabolites of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. J Med Chem 28:311-7 (1985) [PubMed]  Article 
Target
Name:
Dihydropteridine reductase
Synonyms:
DHPR | DHPR_HUMAN | QDPR | SDR33C1
Type:
PROTEIN
Mol. Mass.:
25791.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_54064
Residue:
244
Sequence:
MAAAAAAGEARRVLVYGGRGALGSRCVQAFRARNWWVASVDVVENEEASASIIVKMTDSFTEQADQVTAEVGKLLGEEKVDAILCVAGGWAGGNAKSKSLFKNCDLMWKQSIWTSTISSHLATKHLKEGGLLTLAGAKAALDGTPGMIGYGMAKGAVHQLCQSLAGKNSGMPPGAAAIAVLPVTLDTPMNRKSMPEADFSSWTPLEFLVETFHDWITGKNRPSSGSLIQVVTTEGRTELTPAYF
  
Inhibitor
Name:
BDBM50025879
Synonyms:
4-(1-Methyl-1,2,3,6-tetrahydro-pyridin-4-yl)-phenol | 4-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenol | CHEMBL108967 | CHEMBL537234
Type:
Small organic molecule
Emp. Form.:
C12H15NO
Mol. Mass.:
189.2536
SMILES:
CN1CCC(=CC1)c1ccc(O)cc1 |c:4|
Structure:
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