Reaction Details Report a problem with these data
Target
Dopamine beta-hydroxylase
Ligand
BDBM50026186
Substrate
n/a
Meas. Tech.
ChEBML_59141
Ki
2150000±n/a nM
Citation
 Bargar, TM; Broersma, RJ; Creemer, LC; McCarthy, JR; Hornsperger, JM; Palfreyman, MG; Wagner, J; Jung, MJ Unsaturated heterocyclic amines as potent time-dependent inhibitors of dopamine beta-hydroxylase. J Med Chem 29:315-7 (1986) [PubMed]  Article 
Target
Name:
Dopamine beta-hydroxylase
Synonyms:
DBH | DOPO_BOVIN
Type:
PROTEIN
Mol. Mass.:
68136.39
Organism:
Bos taurus
Description:
ChEMBL_50738
Residue:
610
Sequence:
MQVPSPSVREAASMYGTAVAVFLVILVAALQGSAPAESPFPFHIPLDPEGTLELSWNISYAQETIYFQLLVRELKAGVLFGMSDRGELENADLVVLWTDRDGAYFGDAWSDQKGQVHLDSQQDYQLLRAQRTPEGLYLLFKRPFGTCDPNDYLIEDGTVHLVYGFLEEPLRSLESINTSGLHTGLQRVQLLKPSIPKPALPADTRTMEIRAPDVLIPGQQTTYWCYVTELPDGFPRHHIVMYEPIVTEGNEALVHHMEVFQCAAEFETIPHFSGPCDSKMKPQRLNFCRHVLAAWALGAKAFYYPEEAGLAFGGPGSSRFLRLEVHYHNPLVITGRRDSSGIRLYYTAALRRFDAGIMELGLAYTPVMAIPPQETAFVLTGYCTDKCTQLALPASGIHIFASQLHTHLTGRKVVTVLARDGRETEIVNRDNHYSPHFQEIRMLKKVVSVQPGDVLITSCTYNTEDRRLATVGGFGILEEMCVNYVHYYPQTQLELCKSAVDPGFLHKYFRLVNRFNSEEVCTCPQASVPEQFASVPWNSFNREVLKALYGFAPISMHCNRSSAVRFQGEWNRQPLPEIVSRLEEPTPHCPASQAQSPAGPTVLNISGGKG
  
Inhibitor
Name:
BDBM50026186
Synonyms:
CHEMBL106130 | Methyl-(2-thiophen-2-yl-allyl)-amine
Type:
Small organic molecule
Emp. Form.:
C8H11NS
Mol. Mass.:
153.245
SMILES:
CNCC(=C)c1cccs1
Structure:
Search PDB for entries with ligand similarity: