Reaction Details Report a problem with these data
Target
Stromelysin-1
Ligand
BDBM50468230
Substrate
n/a
Meas. Tech.
ChEMBL_1798596 (CHEMBL4270888)
IC50
50000±n/a nM
Citation
 Stierle, AA; Stierle, DB; Decato, D; Priestley, ND; Alverson, JB; Hoody, J; McGrath, K; Klepacki, D The Berkeleylactones, Antibiotic Macrolides from Fungal Coculture. J Nat Prod 80:1150-1160 (2017) [PubMed]  Article 
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50468230
Synonyms:
A-26771B | CHEMBL1809124
Type:
Small organic molecule
Emp. Form.:
C20H30O7
Mol. Mass.:
382.448
SMILES:
C[C@@H]1CCCCCCCCC[C@H](OC(=O)CCC(O)=O)C(=O)\C=C\C(=O)O1 |r,t:22|
Structure:
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