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Target
Transcriptional activator protein LasR
Ligand
BDBM50468425
Substrate
n/a
Meas. Tech.
ChEMBL_1799501 (CHEMBL4271793)
EC50
110±n/a nM
Citation
 Boursier, ME; Manson, DE; Combs, JB; Blackwell, HE A comparative study of non-native N-acyl l-homoserine lactone analogs in two Pseudomonas aeruginosa quorum sensing receptors that share a common native ligand yet inversely regulate virulence. Bioorg Med Chem 26:5336-5342 (2018) [PubMed]  Article 
Target
Name:
Transcriptional activator protein LasR
Synonyms:
LASR_PSEAE | lasR
Type:
PROTEIN
Mol. Mass.:
26618.24
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_1475312
Residue:
239
Sequence:
MALVDGFLELERSSGKLEWSAILQKMASDLGFSKILFGLLPKDSQDYENAFIVGNYPAAWREHYDRAGYARVDPTVSHCTQSVLPIFWEPSIYQTRKQHEFFEEASAAGLVYGLTMPLHGARGELGALSLSVEAENRAEANRFMESVLPTLWMLKDYALQSGAGLAFEHPVSKPVVLTSREKEVLQWCAIGKTSWEISVICNCSEANVNFHMGNIRRKFGVTSRRVAAIMAVNLGLITL
  
Inhibitor
Name:
BDBM50468425
Synonyms:
CHEBI:56080 | CHEMBL208383
Type:
Small organic molecule
Emp. Form.:
C16H27NO4
Mol. Mass.:
297.3899
SMILES:
CCCCCCCCCC(=O)CC(=O)N[C@@H]1CCOC1=O
Structure:
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