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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50469084
Substrate
n/a
Meas. Tech.
ChEMBL_1802609 (CHEMBL4274901)
IC50
684±n/a nM
Citation
 Pan, L; Zheng, Q; Chen, Y; Yang, R; Yang, Y; Li, Z; Meng, X Design, synthesis and biological evaluation of novel naphthoquinone derivatives as IDO1 inhibitors. Eur J Med Chem 157:423-436 (2018) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50469084
Synonyms:
CHEMBL4287177
Type:
Small organic molecule
Emp. Form.:
C15H9N3O2
Mol. Mass.:
263.2509
SMILES:
O=C1c2nc([nH]c2C(=O)c2ccccc12)-c1cc[nH]c1
Structure:
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