Reaction Details Report a problem with these data
Target
Carbonic anhydrase 4
Ligand
BDBM50469144
Substrate
n/a
Meas. Tech.
ChEMBL_1803458 (CHEMBL4275750)
Ki
941±n/a nM
Citation
 Angeli, A; Trallori, E; Ferraroni, M; Di Cesare Mannelli, L; Ghelardini, C; Supuran, CT Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity. Eur J Med Chem 157:1214-1222 (2018) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 4
Synonyms:
CA-IV | CA4 | CAH4_HUMAN | Carbonate dehydratase IV | Carbonic anhydrase | Carbonic anhydrase 4 (CA IV) | Carbonic anhydrase IV (CA IV)
Type:
Enzyme
Mol. Mass.:
35037.98
Organism:
Homo sapiens (Human)
Description:
P22748
Residue:
312
Sequence:
MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTKAKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
  
Inhibitor
Name:
BDBM50469144
Synonyms:
CHEMBL4293266
Type:
Small organic molecule
Emp. Form.:
C7H8N2O2SSe
Mol. Mass.:
263.18
SMILES:
[#7]-[#6](=[Se;v2])-c1ccc(cc1)S([#7])(=O)=O
Structure:
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