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Target
Serine/threonine-protein kinase A-Raf
Ligand
BDBM50469203
Substrate
n/a
Meas. Tech.
ChEMBL_1803661 (CHEMBL4275953)
IC50
30±n/a nM
Citation
 Ammar, UM; Abdel-Maksoud, MS; Oh, CH Recent advances of RAF (rapidly accelerated fibrosarcoma) inhibitors as anti-cancer agents. Eur J Med Chem 158:144-166 (2018) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase A-Raf
Synonyms:
ARAF | ARAF1 | ARAF_HUMAN | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | RAF serine/threonine protein kinase
Type:
Enzyme
Mol. Mass.:
67610.81
Organism:
Homo sapiens (Human)
Description:
P10398
Residue:
606
Sequence:
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCVVYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLFHGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELLTPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFSTDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSGYYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRKTRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP
  
Inhibitor
Name:
BDBM50469203
Synonyms:
CHEMBL4289810
Type:
Small organic molecule
Emp. Form.:
C30H33ClF3N7O2
Mol. Mass.:
616.077
SMILES:
CN1CCN(CCNc2nccc(n2)C2(CC2)C(=O)Nc2cc(ccc2C)C(=O)Nc2ccc(c(Cl)c2)C(F)(F)F)CC1
Structure:
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