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Target
Quinolone resistance protein NorA
Ligand
BDBM50101815
Substrate
n/a
Meas. Tech.
ChEMBL_1692500 (CHEMBL4043390)
IC50
22800±n/a nM
Citation
 Astolfi, A; Felicetti, T; Iraci, N; Manfroni, G; Massari, S; Pietrella, D; Tabarrini, O; Kaatz, GW; Barreca, ML; Sabatini, S; Cecchetti, V Pharmacophore-Based Repositioning of Approved Drugs as Novel Staphylococcus aureus NorA Efflux Pump Inhibitors. J Med Chem 60:1598-1604 (2017) [PubMed]  Article 
Target
Name:
Quinolone resistance protein NorA
Synonyms:
NORA_STAAU | norA
Type:
PROTEIN
Mol. Mass.:
42273.03
Organism:
Staphylococcus aureus
Description:
ChEMBL_961221
Residue:
388
Sequence:
MNKQIFVLYFNIFLIFLGIGLVIPVLPVYLKDLGLTGSDLGLLVAAFALSQMIISPFGGTLADKLGKKLIICIGLILFSVSEFMFAVGHNFSVLMLSRVIGGMSAGMVMPGVTGLIADISPSHQKAKNFGYMSAIINSGFILGPGIGGFMAEVSHRMPFYFAGALGILAFIMSIVLIHDPKKSTTSGFQKLEPQLLTKINWKVFITPVILTLVLSFGLSAFETLYSLYTADKVNYSPKDISIAITGGGIFGALFQIYFFDKFMKYFSELTFIAWSLLYSVVVLILLVFANGYWSIMLISFVVFIGFDMIRPAITNYFSNIAGERQGFAGGLNSTFTSMGNFIGPLIAGALFDVHIEAPIYMAIGVSLAGVVIVLIEKQHRAKLKEQNM
  
Inhibitor
Name:
BDBM50101815
Synonyms:
CHEBI:7550 | Nicardipine
Type:
Small organic molecule
Emp. Form.:
C26H29N3O6
Mol. Mass.:
479.525
SMILES:
COC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OCCN(C)Cc1ccccc1 |c:4,9|
Structure:
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