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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50469859
Substrate
n/a
Meas. Tech.
ChEMBL_100133 (CHEMBL712412)
Ki
0.031623±n/a nM
Citation
 Haviv, F; Fitzpatrick, TD; Nichols, CJ; Swenson, RE; Mort, NA; Bush, EN; Diaz, G; Nguyen, AT; Holst, MR; Cybulski, VA The effect of NMeTyr5 substitution in luteinizing hormone-releasing hormone antagonists. J Med Chem 36:928-33 (1993) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50469859
Synonyms:
A-75998 | CHEMBL263839
Type:
Small organic molecule
Emp. Form.:
C80H104ClN15O14
Mol. Mass.:
1535.227
SMILES:
CC(C)C[C@H](NC(=O)[C@H](CCCC(N)C(=O)c1ccncc1)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@H](Cc1cccnc1)NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCC(N)C(C)C)C(=O)N1CCC[C@@H]1C(=O)N[C@@H](C)C(N)=O
Structure:
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