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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50470084
Substrate
n/a
Meas. Tech.
ChEMBL_100131 (CHEMBL858015)
Ki
0.020±n/a nM
Citation
 Haviv, F; Fitzpatrick, TD; Nichols, CJ; Bush, EN; Diaz, G; Bammert, G; Nguyen, AT; Johnson, ES; Knittle, J; Greer, J In vitro and in vivo activities of reduced-size antagonists of luteinizing hormone-releasing hormone. J Med Chem 37:701-5 (1994) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50470084
Synonyms:
CHEMBL428299
Type:
Small organic molecule
Emp. Form.:
C64H85ClN14O11
Mol. Mass.:
1261.9
SMILES:
CCNC(=O)[C@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCNC(=O)c1cccnc1)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CCc1ccc(Cl)cc1 |wU:61.66,12.20,wD:23.28,31.46,5.4,67.70,48.50,(21.23,-6.64,;21.25,-8.17,;19.93,-8.96,;18.58,-8.2,;17.28,-8.96,;18.55,-6.69,;19.77,-5.8,;19.25,-4.36,;17.71,-4.36,;17.29,-5.81,;15.96,-6.56,;15.94,-8.1,;14.62,-5.8,;14.64,-4.26,;15.97,-3.49,;15.99,-1.95,;17.33,-1.19,;17.35,.34,;18.68,1.12,;16,1.13,;13.3,-6.56,;11.96,-5.78,;11.97,-4.23,;10.62,-6.52,;10.61,-8.07,;11.94,-8.87,;13.26,-8.09,;11.91,-10.39,;9.29,-5.75,;7.94,-6.51,;7.94,-8.04,;6.62,-5.74,;6.72,-4.2,;5.49,-3.24,;6.01,-1.78,;4.65,-.75,;5.32,.63,;4.46,1.93,;5.13,3.32,;2.88,1.79,;2.04,3.08,;.46,2.96,;-.18,1.58,;.71,.29,;2.24,.42,;5.29,-6.49,;3.94,-5.72,;3.94,-4.17,;2.61,-6.48,;2.59,-8.01,;3.91,-8.8,;3.91,-10.33,;5.26,-11.12,;6.59,-10.36,;7.91,-11.14,;6.61,-8.81,;5.27,-8.04,;1.29,-5.69,;1.3,-4.14,;-.05,-6.45,;-.06,-8.01,;-1.38,-5.68,;-1.38,-4.14,;-.03,-3.39,;-2.73,-6.43,;-4.05,-5.65,;-4.03,-4.13,;-5.41,-6.42,;-5.41,-7.96,;-4.08,-8.75,;-2.67,-8.13,;-1.63,-9.27,;-2.42,-10.61,;-1.96,-12.07,;-2.99,-13.2,;-4.5,-12.88,;-4.97,-11.41,;-3.92,-10.29,;-6.73,-5.65,;-8.05,-6.42,;-8.08,-7.93,;-9.38,-5.62,;-10.86,-6.52,;-12.37,-5.69,;-13.83,-6.59,;-15.34,-5.77,;-15.4,-4.04,;-17.04,-3.56,;-13.92,-3.14,;-12.4,-3.98,)|
Structure:
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