Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50471890
Substrate
n/a
Meas. Tech.
ChEMBL_53633 (CHEMBL666662)
Ki
43652±n/a nM
Citation
 Selassie, CD; Gan, WX; Kallander, LS; Klein, TE Quantitative structure-activity relationships of 2, 4-diamino-5-(2-X-benzyl)pyrimidines versus bacterial and avian dihydrofolate reductase. J Med Chem 41:4261-72 (1998) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50471890
Synonyms:
CHEMBL132812
Type:
Small organic molecule
Emp. Form.:
C11H11FN4
Mol. Mass.:
218.2302
SMILES:
Nc1ncc(Cc2ccccc2F)c(N)n1
Structure:
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