Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50472581
Substrate
n/a
Meas. Tech.
ChEMBL_1514 (CHEMBL616346)
Ki
6.0±n/a nM
Citation
 Vacher, B; Bonnaud, B; Funes, P; Jubault, N; Koek, W; Assié, MB; Cosi, C; Kleven, M Novel derivatives of 2-pyridinemethylamine as selective, potent, and orally active agonists at 5-HT1A receptors. J Med Chem 42:1648-60 (1999) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50472581
Synonyms:
CHEMBL43097
Type:
Small organic molecule
Emp. Form.:
C22H21Cl2N5O
Mol. Mass.:
442.341
SMILES:
Clc1ccc(cc1Cl)C(=O)N1CCC(CNCc2cccc(n2)-n2cccn2)=CC1 |c:30,(23.53,-13.82,;22.19,-13.07,;20.87,-13.84,;19.56,-13.1,;19.55,-11.57,;20.85,-10.79,;22.18,-11.53,;23.5,-10.76,;18.21,-10.83,;18.21,-9.3,;16.9,-11.6,;15.41,-11.88,;15.18,-10.54,;13.93,-9.74,;12.52,-10.56,;11.09,-9.74,;9.67,-10.56,;8.25,-9.74,;8.25,-8.11,;6.83,-7.29,;5.41,-8.11,;5.41,-9.74,;6.83,-10.56,;3.98,-10.56,;2.32,-10.53,;1.8,-12.05,;3.09,-13.05,;4.45,-12.13,;15.31,-9.45,;16.74,-10.12,)|
Structure:
Search PDB for entries with ligand similarity: