Reaction Details
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Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Ligand
BDBM50366480
Substrate
n/a
Meas. Tech.
ChEMBL_162010 (CHEMBL764181)
Kd
69±n/a nM
Citation
Ishchenko, AV; Shakhnovich, EI SMall Molecule Growth 2001 (SMoG2001): an improved knowledge-based scoring function for protein-ligand interactions. J Med Chem 45:2770-80 (2002) [PubMed] Article More Info.:
Target
Name:
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Synonyms:
2A5A_HUMAN | PPP2R5A | Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Type:
PROTEIN
Mol. Mass.:
56194.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_161424
Residue:
486
Sequence:
MSSSSPPAGAASAAISASEKVDGFTRKSVRKAQRQKRSQGSSQFRSQGSQAELHPLPQLKDATSNEQQELFCQKLQQCCILFDFMDSVSDLKSKEIKRATLNELVEYVSTNRGVIVESAYSDIVKMISANIFRTLPPSDNPDFDPEEDEPTLEASWPHIQLVYEFFLRFLESPDFQPSIAKRYIDQKFVQQLLELFDSEDPRERDFLKTVLHRIYGKFLGLRAFIRKQINNIFLRFIYETEHFNGVAELLEILGSIINGFALPLKAEHKQFLMKVLIPMHTAKGLALFHAQLAYCVVQFLEKDTTLTEPVIRGLLKFWPKTCSQKEVMFLGEIEEILDVIEPTQFKKIEEPLFKQISKCVSSSHFQVAERALYFWNNEYILSLIEENIDKILPIMFASLYKISKEHWNPTIVALVYNVLKTLMEMNGKLFDDLTSSYKAERQREKKKELEREELWKKLEELKLKKALEKQNSAYNMHSILSNTSAE
Inhibitor
Name:
BDBM50366480
Synonyms:
ADENOSINE TRIPHOSPHATE | ATP
Type:
Small organic molecule
Emp. Form.:
C10H16N5O13P3
Mol. Mass.:
507.181
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O |r|
Structure:
