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Target
Histamine H4 receptor
Ligand
BDBM50127607
Substrate
n/a
Meas. Tech.
ChEMBL_87229 (CHEMBL696449)
Ki
3800±n/a nM
Citation
 Kitbunnadaj, R; Zuiderveld, OP; De Esch, IJ; Vollinga, RC; Bakker, R; Lutz, M; Spek, AL; Cavoy, E; Deltent, MF; Menge, WM; Timmerman, H; Leurs, R Synthesis and structure-activity relationships of conformationally constrained histamine H(3) receptor agonists. J Med Chem 46:5445-57 (2003) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50127607
Synonyms:
(1R,2R)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1R,2R)-2-(3H-Imidazol-4-yl)-cyclopropylamine | 2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL13559 | VUF-5296
Type:
Small organic molecule
Emp. Form.:
C6H9N3
Mol. Mass.:
123.1558
SMILES:
N[C@@H]1C[C@H]1c1cnc[nH]1
Structure:
Search PDB for entries with ligand similarity: