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Target
Alpha-1A adrenergic receptor
Ligand
BDBM50474635
Substrate
n/a
Meas. Tech.
ChEMBL_33594 (CHEMBL652803)
Ki
148±n/a nM
Citation
 Altenbach, RJ; Khilevich, A; Kolasa, T; Rohde, JJ; Bhatia, PA; Patel, MV; Searle, XB; Yang, F; Bunnelle, WH; Tietje, K; Bayburt, EK; Carroll, WA; Meyer, MD; Henry, R; Buckner, SA; Kuk, J; Daza, AV; Milicic, IV; Cain, JC; Kang, CH; Ireland, LM; Carr, TL; Miller, TR; Hancock, AA; Nakane, M; Esbenshade, TA; Brune, ME; O'Neill, AB; Gauvin, DM; Katwala, SP; Holladay, MW; Brioni, JD; Sullivan, JP Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem 47:3220-35 (2004) [PubMed]  Article 
Target
Name:
Alpha-1A adrenergic receptor
Synonyms:
ADA1A_BOVIN | ADRA1A | ADRA1C | Alpha 1A-adrenoceptor | Alpha 1A-adrenoreceptor | Alpha-1C adrenergic receptor | Cerebral cortex alpha adrenergic receptor | adrenergic Alpha1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51492.08
Organism:
CALF
Description:
adrenergic Alpha1 0 CALF
Residue:
466
Sequence:
MVFLSGNASDSSNCTHPPPPVNISKAILLGVILGGLILFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNVWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQKRGLMALLCVWALSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNAQVGGSGVTSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFRPSETVFKIAFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRKQSSKHTLGYTLHAPSHVLEGQHKDLVRIPVGSAETFYKISKTDGVCEWKIFSSLPRGSARMAVARDPSACTTARVRSKSFLQVCCCLGPSTPSHGENHQIPTIKIHTISLSENGEEV
  
Inhibitor
Name:
BDBM50474635
Synonyms:
CHEMBL109827
Type:
Small organic molecule
Emp. Form.:
C15H17N3O2
Mol. Mass.:
271.3144
SMILES:
COC(=O)Nc1cccc2C(CCCc12)c1c[nH]cn1
Structure:
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