Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50027790
Substrate
n/a
Meas. Tech.
ChEBML_146486
IC50
8.6±n/a nM
Citation
 Rice, KC; Konicki, PE; Quirion, R; Burke, TR; Pert, CB Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo. J Med Chem 26:1643-5 (1983) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOR-1 | Mor | OPIATE Mu | OPRM_MOUSE | Opioid receptors; mu and delta | Oprm | Oprm1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44431.62
Organism:
MOUSE
Description:
OPIATE Mu OPRM1 MOUSE::P42866
Residue:
398
Sequence:
MDSSAGPGNISDCSDPLAPASCSPAPGSWLNLSHVDGNQSDPCGPNRTGLGGSHSLCPQTGSPSMVTAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGNILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSTIEQQNSARIRQNTREHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50027790
Synonyms:
3,5-Dibromo-2-hydroxy-N-(3-trifluoromethyl-phenyl)-benzamide | 3,5-Dibromo-2-hydroxy-N-(3-trifluoromethyl-phenyl)-benzamide(fluorophen) | CHEMBL283552 | Fluorosalan
Type:
Small organic molecule
Emp. Form.:
C14H8Br2F3NO2
Mol. Mass.:
439.022
SMILES:
Oc1c(Br)cc(Br)cc1C(=O)Nc1cccc(c1)C(F)(F)F
Structure:
Search PDB for entries with ligand similarity: