Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 3
Ligand
BDBM50475645
Substrate
n/a
Meas. Tech.
ChEMBL_333290 (CHEMBL859107)
EC50
316±n/a nM
Citation
 Semple, G; Skinner, PJ; Cherrier, MC; Webb, PJ; Sage, CR; Tamura, SY; Chen, R; Richman, JG; Connolly, DT 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. J Med Chem 49:1227-30 (2006) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 3
Synonyms:
G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44498.06
Organism:
Homo sapiens (Human)
Description:
GPR109B 0 HUMAN::P49019
Residue:
387
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
  
Inhibitor
Name:
BDBM50475645
Synonyms:
CHEMBL202157
Type:
Small organic molecule
Emp. Form.:
C10H11N3O3
Mol. Mass.:
221.2126
SMILES:
COCCn1nnc2cc(ccc12)C(O)=O
Structure:
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