Reaction Details Report a problem with these data
Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50477818
Substrate
n/a
Meas. Tech.
ChEMBL_459966 (CHEMBL943094)
Ki
3162±n/a nM
Citation
 Woods, CR; Hack, MD; Allison, BD; Phuong, VK; Rosen, MD; Morton, MF; Prendergast, CE; Barrett, TD; Shankley, NP; Rabinowitz, MH Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands. Bioorg Med Chem Lett 17:6905-9 (2007) [PubMed]  Article 
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50477818
Synonyms:
CHEMBL399919
Type:
Small organic molecule
Emp. Form.:
C20H19BrN2O3S2
Mol. Mass.:
479.41
SMILES:
Brc1ccc(C(=O)N2CCCCC2)c(NS(=O)(=O)c2csc3ccccc23)c1
Structure:
Search PDB for entries with ligand similarity: