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Target
Neuropeptide S receptor
Ligand
BDBM50477897
Substrate
n/a
Meas. Tech.
ChEMBL_460809 (CHEMBL943824)
EC50
8.1±n/a nM
Citation
 Camarda, V; Trapella, C; Calo, G; Guerrini, R; Rizzi, A; Ruzza, C; Fiorini, S; Marzola, E; Reinscheid, RK; Regoli, D; Salvadori, S Synthesis and biological activity of human neuropeptide S analogues modified in position 2. J Med Chem 51:655-8 (2008) [PubMed]  Article 
Target
Name:
Neuropeptide S receptor
Synonyms:
Gpr154 | NPSR1_MOUSE | Npsr1 | Pgr14
Type:
PROTEIN
Mol. Mass.:
42447.53
Organism:
Mus musculus
Description:
ChEMBL_445691
Residue:
371
Sequence:
MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALVAEEWGSFYSSFKTEQLITLWVLFVVTIVGNSVVLFSTCRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLAIISVIYGLVIRTIWMKSKTHETVISNCSDGKLCCSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFNVLPDTKERFYASVIIQNLPALNSAINPLIYCIFSSSICSPCKMQRSQDSRMTYRERSERHEMQILSKPEFI
  
Inhibitor
Name:
BDBM50477897
Synonyms:
CHEMBL427638
Type:
Small organic molecule
Emp. Form.:
C94H155N31O28S
Mol. Mass.:
2199.492
SMILES:
[H][C@]1(Cc2ccccc2CN1C(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O
Structure:
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