Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50478794
Substrate
n/a
Meas. Tech.
ChEMBL_530357 (CHEMBL968453)
Ki
11000±n/a nM
Citation
 Stefek, M; Snirc, V; Djoubissie, PO; Majekova, M; Demopoulos, V; Rackova, L; Bezakova, Z; Karasu, C; Carbone, V; El-Kabbani, O Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling. Bioorg Med Chem 16:4908-20 (2008) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50478794
Synonyms:
CHEMBL477942
Type:
Small organic molecule
Emp. Form.:
C20H19KN2O2
Mol. Mass.:
358.4754
SMILES:
n/a
Structure:
Search PDB for entries with ligand similarity: