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Target
Thymidine phosphorylase
Ligand
BDBM50479931
Substrate
n/a
Meas. Tech.
ChEMBL_563518 (CHEMBL961805)
IC50
75930±n/a nM
Citation
 Khan, KM; Ambreen, N; Hussain, S; Perveen, S; Choudhary, MI Schiff bases of 3-formylchromone as thymidine phosphorylase inhibitors. Bioorg Med Chem 17:2983-8 (2009) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TYPH_ECOLI | TdRPase | Thymidine Phosphorylase (TP) | deoA | tpp | ttg
Type:
Enzyme
Mol. Mass.:
47198.54
Organism:
Escherichia coli
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM50479931
Synonyms:
CHEMBL490853
Type:
Small organic molecule
Emp. Form.:
C23H14ClNO3
Mol. Mass.:
387.815
SMILES:
Clc1ccc(\N=C\c2coc3ccccc3c2=O)c(c1)C(=O)c1ccccc1
Structure:
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